Jo-Wilfried Tsonga looms as a potential second-round opponent in a possible rematch of their AO 2008 decider.
Aiming for a 21st Grand Slam trophy and a 100th career singles title, Federer will open against Denis Istomin. Murray is playing in Australia under his protected ranking of world number two, which is used to help players who have suffered long-term injuries.
"I'm so close, I'll give it a go, " Federer said.
Those two, and seventh seed Dominic Thiem, are in the same quarter as Alexander Zverev, who could meet Djokovic in the semifinals but must first plot his way past Aljaz Bedene in the opening round. If it would happen defending this title, I would gladly accept it.
During his Australian Open qualifying victory over Jurij Rodionov, Great Britain's Dan Evans pulled off one of the most remarkable shots we can remember seeing.
Andy Murray will make his return to the Australian Open with a tough first-round match against Roberto Bautista Agut.
Alex de Minaur, the only Australian men's seed in the draw at number 27, opens against Pedro Sousa, while other prominent first-round matchups for the locals include John Millman against Federico Delbonis, and Nick Kyrgios in a mouth-watering encounter against big-serving Canadian Milos Raonic, the 16th seed.
"To finally get that (title) here was so special, it's the happy slam". Among those looking to halt Serena's charge: world number one Simona Halep, defending champion Caroline Wozniacki and US Open victor Naomi Osaka.
The Spanish 22nd seed defeated Djokovic on his way to the title in Doha last week while concerns about Murray's fitness grew as he struggled through a practice match against Djokovic at Melbourne Park on Thursday. "I'm just enjoying every minute of it".
It will be the first time for Wang to head into a Grand Slam as a seeded player.