Sadio Mane and Andy Robertson were expected absentees through injury.
Burnley, without a win since September, showed five changes themselves but it was apparent from the outset they were intent on hassling and harrying their visitors out of their stride.
So for Liverpool to get the late goal how they did, it was just a rush of emotion.
A physical opening 25 minutes saw plenty of hard tackles and few chances on goal, with Joe Gomez stretchered off in the 23rd minute and replaced by Trent Alexander-Arnold after a Ben Mee challenge.
From a right-wing corner, Alisson blocked the initial effort at his goal but Barnes caused a scramble with a lunge towards the rebound and Cork eventually converted the loose ball. Keïta found some space on the left, Origi coolly played a ball backwards out of the area and Milner took a brief look up before clipping a low shot from the edge inside Hart's left-hand post.
With the ball looking as if it might hit the cross-bar, the England man pushed the ball upwards and presented Origi with a simple headed finish into an open net.
Sean Dyche says his team have lost what he's calling "the eye of the tiger" - but if Liverpool's front three start to click, Burnley might find themselves in the eye of a storm.
Liverpool are second in the league with 36 points from 14 games while Burnley are second from bottom with nine points.