The toss will take place at 6:30 PM IST.
With Virat Kohli rested ahead of the bigger battles Down Under, India's stand-in skipper Rohit Sharma will have the task getting India's record better against the Windies.
Most of the players who are part of the T20 squad have played the IPL for various franchisees and know the Indian pitches very well, particularly, Kolkatta's Eden Garden which can accommodate more than one lakh spectators.
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Wicketkeeper-batsmen Rishabh Pant and Dinesh Karthik have been named in the 12-man squad but the Delhi Daredevils youngster, who had set Indian Premier League 2018 on fire, is all set to don the gloves.
Dhoni has been left out of India's T20 squad for the home series against West Indies and, more significantly, India's tour of Australia.
Karthik first revived India's chase with Manish Pandey (19) and then found an able ally in Pandya, whose clever and nerveless batting stood out. Wicket-keeper batsman MS Dhoni will also not feature in the upcoming series.
Live Broadcast: Star Sports 1 and Star Sports 1 HD (English commentary) and Star Sports 3 and Star Sports 3 HD (Hindi Commentary).
The Indian seam attack will be led by Bhuvneshwar Kumar and Jasprit Bumrah, which now includes additional variation in the form of left-arm quick Khaleel Ahmed.
Captain Brathwaite, who famously clubbed four consecutive sixes off Ben Stokes to win the World Cup here two years ago, will also be counted on as a match victor for the side missing the services of talisman Chris Gayle who declined selection.
Star all-rounder Andre Russell was forced to skip the West Indies team's practice session on the eve of their first T20I against India after missing a connecting flight from Dubai. The Eden track promises a run feast with a bit of grass on the surface affording even bounce and the ball expected to come on to the bat nicely.
But Brathwaite made India work for their victory, taking 2-11 with the ball to reduce the home side to a nervous 45-4 in reply before Dinesh Karthik saw them home with an unbeaten 31.