Despite becoming a major force in recent years, City have a miserable record at Liverpool, where they have not won in the Premier League since 2003.
There is a theory that although Klopp is able to defeat Guardiola in a one-off game, the latter will ultimately prevail over the course of a league campaign because of the control his football exerts and the squad he has.
He said: "Obviously we won the last three games against City".
Guardiola's team selection is, as ever, much trickier to forecast.
Jurgen Klopp has described Pep Guardiola as the best manager in the world ahead of Liverpool's showdown with Manchester City on Sunday. The Liverpool goalkeeper has conceded only thrice, a number of par with Manchester City's number one.
Klopp says he has huge respect for the way in which City play under Guardiola and described it as "exciting" to face his teams. The Premier League encounter will have much stakes riding on it as the victor of it will prove its title credentials.
I will be splitting my stake, backing Over 3.5 goals at anything around [2.8] before kickoff and then if Over 2.5 goals reaches [2.0] in running, I will be placing the other half of my stake on that.
With both teams sitting on 19 points, a win for the Reds would allow them to start to pull away from the pack and put pressure on City, Tottenham and Chelsea.
However, the Premier League fixture, which I was working at, was nip and tuck, and City...
Aguero may have lost a yard or two of speed through age and injuries, but he clearly still keeps one of the best full-backs in the country honest in training sessions. In the last 15 minutes they had two big chances and scored a goal.
"You have to be ready, you need a fantastic football team - which thank God I have - with outstanding character, ready to be really fearless, ready to make mistakes".
Attack: Riyad Mahrez is pushing for a recall but I think we'll see Leroy Sane keeping his place in attack while Raheem Sterling should also retain his spot in the front three so Mahrez may have to make do with a place on the bench.
"It will be hard work, no problem with that, everybody knows it".