The US First Lady arrived in the country on Tuesday, and was met by a government delegation, led by Ghana's very own First Lady, Rebecca Akufo-Addo.
She offered to spend a historical moment with mothers and babies at the Greater Accra Regional (Ridge) Hospital.
"Issues to do with the welfare of children will take centre stage since the two first ladies have similar interests and passion for children", said Juma.
Melania Trump has visited a former slave holding facility on the coast of Ghana and says she will "never forget" it.
Then-President Barack Obama and his family toured the castle in 2009.
Upon arrival in Nairobi, she will be expected to visit State House as her first stop.
The U.S. first lady spent just under an hour on a guided tour of the 17th-century castle, where slaves were held before they were shipped across the Atlantic Ocean.
"I will never forget (the) incredible experience and the stories I heard".
"Her trip will focus on maternal and newborn care in hospitals, education for children, the deep culture and history woven into each African country, and how the United States is supporting each country on its journey to self-reliance", the White House said before she left.
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In fact, the first lady went out of her way to make her outfit look more like last year's version; for her first outing on Wednesday morning, which saw her paying a visit to local chiefs in order to get permission to visit the castle, Melania had accessorized the jacket with a thick leather belt.
On her four-country, week-long tour of Africa, Trump is aiming to cast a more positive light on her embattled husband's administration and its "America First" agenda.
Melania did make one change to the look however; having chosen to pop the collar of the jacket for her visit to the military base previous year, the first lady opted to wear it down in a more conservative style while touring the castle.
In August of this year, Melania re-wore a $1,280 striped shirt dress by designer Adam Lippes, having first stepped out in the number back in March during a visit to Palm Beach's St. Mary's Medical Center, where she delivered Easter baskets to young children.
In addition to Ghana, she is due to visit Malawi, Kenya and Egypt before returning to Washington early on Oct 7.