He limped off after scoring in their 2-0 win over Brighton on Saturday but still took part in training.
Hoffenheim are expected to be without captain Kevin Vogt because of a thigh injury, as well as defenders Ermin Bicakcic and Havard Nordtveit. Inexperienced trio Stefan Posch (21), Kevin Akpoguma (23) and Justin Hoogma (20) deputise once more.
On Hoffenheim's game against Man City, he added: "The first ever meeting between the clubs and City need to get a result after their shock home reverse to Lyon on Matchday 1".
City fell behind to a goal from Ishak Belfodil inside 60 seconds at the Rheine-Neckar-Arena and while Sergio Agüero soon equalised they had to wait until the 87th minute for Silva's finish to claim victory. Sometimes you go through bad times and good times.
"He's coming out in press conferences constantly having a go at players, having a go at the people above for not getting what he wants". Guardiola was in charge of Bayern that day. Either team could have won the game late on, but it finished 2-2 at the Groupama Stadium.