Although Guardiola clearly has no intention of letting De Bruyne leave, he added that there is a clause in his new City deal - something which will come as a surprise to many. He won three La Liga titles, two Champions Leagues and two Club World Cups during four seasons in charge.
De Bruyne signed his current contract in January and it ties him to City until 2023.
Like De Bruyne, Guardiola has committed his future to City with a contract extension and the former Barcelona and Bayern Munich coach is settled at the Etihad Stadium.
City have hardly struggled without De Bruyne, but compared to last season's cruise to the title, a draw at newly-promoted Wolves and a tight 2-1 victory at home to struggling Newcastle have represented a challenging start to the campaign.
"My teams are going to try to play how I want", he said to Jorge Valdano on Universo Valdano. He does everything. I recently met his parents and you only understand how children are when you have met the parents.
"The clause is €250m (£223m)".
"I will finish again where I started.my last steps will be in the youth teams - I hope at Barca. I'm sorry, he's not for sale".
"I don't know anything about that", the Manchester City manager said.
Guardiola is happy with the strength and fitness of his squad after noting a month ago that his players were not at maximum effectiveness.
"Here [City] I feel very good, very protected from football", he said. "I'm at the club that interests me".