Rumours say that the midfielder is un fit but Unai Emery might risk him today since they are playing a big team.
Otamendi comes for too many aerial balls he can't win, Kompany is turned too often on the ground. That record would not change on Sunday as Manchester City strolled to a 2-0 win.
Arsenal themselves travel to play Chelsea next weekend and Emery will need to make sure his squad regroup. Sokratis, Lucas Torreira, Stephan Lichtsteiner and Bernd Leno were all signed as well as the young prodigy, Matteo Guendouzi.
If City is to take a foothold within the game, it will down their right side. After sending Calum Chambers on loan to Fulham a few days ago, Emery seems to be going with the idea of fielding Sokratis and Mustafi as his preferred choice of central defensive pairing. Nacho Monreal and Sead Kolasinac are set to miss the game owing to injuries and Emery may have to ask Ainsley Maitland-Niles to deputise in the backline.
The Argentine came up against the Gunners on three occasions last season and directly contributed to a goal in each of those, registering one assist and scoring twice himself - including once in the EFL Cup final.
Unai Emery is clearly not afraid to experiment.
Bernardo Silva has earned huge praise from Guardiola in pre-season and is expected to play a key role for City. Mesut Ozil and David Silva will be the two playmakers on the pitch and both know if they can get the balls quickly to the forward areas, it opens up opportunities for the strikers. Of course, against centre-backs as composed as John Stones and Aymeric Laporte, and a goalkeeper as confident as Ederson, actually winning possession is somewhat hard.
Koscielny, now out with an ankle injury, captained the side in place of Per Mertesacker last season.
Arsenal are without a win in their last five meetings against Manchester City. There's the promise of a more diligent, alert, tactically-astute brand of football with a higher press - and what better petri dish than a match against the runaway champions, a team that pounces on your weaknesses, insecurities and callowness more ruthlessly than anyone since. well. the Arsenal of 2000-2004.
The Gunners entertain Pep Guardiola's champions at the Emirates on Sunday.
"My main thing is to start the Premier League, the cup, the Europa League and then my objective is to improve each player with their qualities and our work with them".
Arsenal have received six red cards on opening day games, most by any side.
Where is the Arsenal vs Manchester City, Premier League fixture being played?