As the fifth set dragged on and on, the American Isner appeared more visibly exhausted and had to survive more scares on his own serve than Anderson. Isner was serving first, with Anderson then having to hold each time in order to stay alive in the match.
Competing for the University of Georgia Bulldogs between 2003-2007 and he had an incredible result in both singles and doubles, winning 283 matches for the Bulldogs overall!
Anderson will play again in the final on Sunday - hopefully there, a victor will be decided in four sets or less.
The Canadian and partner Yifan Xu of China, seeded sixth, lost 6-3, 4-6, 7-5 to No. 12 seeds Nicole Melichar of the USA, and Kveta Peschke of the Czech Republic in the Wimbledon semifinals on Friday.
In the third set, the 33-year-old American fended off two set points and won the tiebreak 11-9.
In a match between two of the game's biggest servers, Anderson started the match with a double-fault. Djokovic owns 12 Slam trophies, three from Wimbledon. Though Raonic outgunned Isner in that respect - 31 to 25 - he was unable to see through service games as convincingly.