After a good day with the ball, Pandya was handed a promotion to No. 4 with India still 48 away, and he did not disappoint.
This was India's sixth successive T20I series win. Chasing 199 for victory, Rohit remained not out on 100 off 56 balls, and including 11 fours and five sixes.
He was ably supported by skipper Virat Kohli, who scored a 29-ball 43.
Earlier, England batsmen faced resistance from Indian bowlers as the latter kept picking wickets on regular intervals but the batsmen put up a decent show and kept the scoreboard running.
Now, after scoring just 61 runs off 54 balls in four Twenty20 internationals, Root and England need to consider whether his omission is just temporary or whether it is in everyone's best interests for it to become permanent.
The hosts ringed in just one change, Ben Stokes coming in place of Joe Root.
England looked to be on course for 220-230 runs, admitted Virat Kohli in the decisive third T20 against India on Sunday in Bristol.
The Indian captain began to gain in confidence as he hit another six off Plunkett before he fell victim of Jordan in the 15th over, caught and bowled by the bowler in a soft dismissal.
Kuldeep's absence, however, did not affect India much as they thrashed the hosts by 7 wickets to win the series.
In the end, India clinching the T20 series 2-1. The rest of the batsmen could not take England past the 200-mark but still posted a more than par total.
The powerplay yielded 73 and the only realistic chance India had during the early carnage was a mistimed slog sweep from Buttler in Yuzvendra Chahal's first over, but the ball popped out of Siddarth Kaul's hands.
Buttler was dropped by Siddharth Kaul when on 20 with Chahal being the unfortunate bowler. Roy completed his half-century.
The breakthrough came just as India were starting to wonder where to bowl to the opening duo.
It started with Eoin Morgan's slog and Hales's caught behind in the same over, and trickled on to his final over. He went off for some treatment but Morgan did India a favour with another skier off the very next ball. Dhoni took a simple catch. Pandya was not done yet, as he had Alex Hales (30) caught behind too. I wouldn't say Ben Stokes is an automatic pick but you will always be tempted to get him back in the side when he's fit'. The attack intensified with Jason Roy overtaking his opening partner to a quick fifty in the space of next four overs - laced with five sixes, as the Indians continued to bowl full.