The National Weather Service is expected to send a survey team Thursday to evaluate the damage and confirm whether strong winds or a tornado caused the damage.
There were no initial reports of injuries, according to the Associated Press.
A Nissan dealership, U-Haul store, Ashley Furniture and Smokey Bones restaurant were also damaged in the storm, the Times Leader said.
Early Thursday morning, aerial footage aired live on Eyewitness News showed the full extent of the damage at a major shopping hub in Wilkes-Barre Township.
Another of the hardest hit areas, Wilkes-Barre Township in Luzerne County.
Emergency crews from across the region have also been called in, with the American Red Cross on the scene assisting the first responders.
The Wilkes-Barre Township Police Department posted on Facebook that there were "multiple collapsed/damaged buildings" in the area of Mundy Street, and asked drivers to avoid the area. Debris lay scattered in parking lots and on streets and sidewalks.
"I was washing dishes in the back, my manager had us secure the doors", Isles said.
While tornadoes can occur at any time of the year in Pennsylvania, the state sees them most frequently in May, June and July, with June historically bringing the most. "We had tables and chairs flying through the windows".
Isles said he suffered a minor scrape on his arm while he helped to get other people in the restaurant to safety.