After much talk about how good he is going to be, including comparing himself to Muhammad Ali and Floyd Mayweather, Fury did not encounter much difficulty in forcing the outsized Seferi to quit before the fifth round at Manchester Arena.
Sporadic thick right hands from Fury had Seferi on the back-foot in the fourth, and his corner evidently made a decision to spare him further drawn-out punishment when they summoned Edwards and withdrew their man at the end of the round.
Frank Warren, promoter to both Fury and Frampton, confirmed that the heavyweight would appear on the Belfast bill as he continues his comeback.
Former heavyweight champion Fury wins on boxing comeback
The contest at times resembled a pantomine with Fury gurning and throwing his arms into the air through much of the opening round. "I was happy with it".
"I'll be better next time".
"At the end of the day, he needs rounds and he got four under his belt".
An nearly comical fight saw Fury with a six-inch height advantage over the Albanian - and his laughing, play-acting and tongue-pulling suggested he was not having to exert himself too much in his first fight for two and a half years. "I am determined to enjoy my career this time around and not take anything for granted".
If he looked a little more serious from the second round onwards, it still felt like something of a non-event as the limited Seferi tried in vain to even reach Fury's head with his sluggish right uppercuts.
But Fury was disappointed by the attitude of 39-year-old Seferi, who was giving away more than 50lb and almost a foot of height difference on the night.
After twice pulling out of rematches with Klitschko, Fury admitted problems with depression, excessive drinking and cocaine use before it was revealed he failed drugs test in February 2015. He received his boxing licence in January after accepting a backdated two-year doping ban.
"On 18 August at Windsor Park in Belfast", Warren responded when asked when we could expect to see Fury back in the ring. "In the meantime we have to get Tyson more competitive fights".