The photographs in question were taken with his Russian fans when he was visiting St. Petersburg. He was described as "weak" "sick" and "skinny".
The 54-year-old is now touring Europe with rock supergroup Hollywood Vampires.
However some fans, who saw him perform with his band the Hollywood Vampires in Hamburg, said that he looked "happy and healthy" when he arrived in Germany.
Where many fans are concerned for Depp's health, others feel like it might be because of the legal issues he has been facing for some time.
"Omg I hope he's ok", wrote one user.
One fan took to her Instagram account to post a pic featuring her and the actor on May 27, and she assured everyone that while he seemed to be 'a little exhausted, ' he did not look ill at all. "It doesn't mean he's sick or dying", a netizen tweeted.
Meanwhile, PEOPLE also reports that Depp is suing the British tabloid The Sun, columnist Dan Wootton and publisher News Group Newspapers Limited for libel over a story that called him a "wife beater".
Johnny is now involved in a legal dispute with his former management company, claiming they mismanaged his millions.
It was reported by Empire a year ago the actor was set to star in Richard Says Goodbye.
During his $7 million divorce from Heard, he faced allegations that he was verbally and physically abusive. Depp's music and film career seems to be thriving, and he doesn't owe anyone an explanation about the changes to his appearance.