MI5 chief Andrew Parker will warn of the continued threat of attacks on Britain from the so-called Islamic State and Russian Federation in a rare speech outside the country on Monday.
Against the backdrop of Brexit negotiations, the chief stressed that European intelligence agencies must rely on "shared cooperation more than ever".
In his first public comments about the nerve agent attack in March, Mr Parker accused the Kremlin of "flagrant breaches of global rules".
The attack, with the novichok toxin, marked the first use of a nerve agent in Europe since the Second World War.
Parker said that Britain does not wish to exacerbate tension and to return to "dangerous times" that Europe experienced during the Cold war, but Russian Federation will answer for their actions.
Parker will thank European security agencies for their support in the investigation following the Manchester bombing that claimed 22 lives almost a year ago.
Twelve terror plots have been thwarted by MI5 and police since last year's Westminster attack in London, bringing the total number of thwarted incidents since 2013 to 25.
The UK, as Europe's preeminent intelligence power, is seeking a new security pact with the bloc to ensure it gets continued access to secrets from major European Union countries as it seeks to clinch a broader Brexit deal.
The Kremlin will also be accused of "flagrant breaches of worldwide rules" in the speech where Mr Parker will also lambast its "aggressive and pernicious actions".
He will describe how the Counter Terrorism Group, which is made up of 30 European domestic security services, is the "largest multinational counter-terrorism enterprise in the world".
He will condemn the Russian "propaganda machine" in attempting to spread a "fog of lies".
Russia has denied any involvement in the attack and has challenged Britain to reveal evidence to back up its claim that the Russian state was likely behind it.