Two years ago to the day, West Ham waved goodbye to Upton Park in a thrilling 3-2 win over United on a night of high emotion in East London.
The Austrian global appeared to have the better of United defender Chris Smalling from the moment he turned past him in the seventh minute and fired straight at United goalkeeper David De Gea from 20 yards.
In a boring game with few quality chances, United defender Luke Shaw came closest to scoring when he had a shot turned onto the post in the first half.
Paul Pogba was struggling to exert influence on the game and the midfielder should have scored from Antonio Valencia's right-wing cross, instead heading wide.
If the former Manchester United manager needs to make changes then he has a bench full of options, including Andy Carroll and Jordan Hugill.
With second spot in the bag, Mourinho is setting a new target for United's last game of the Premier League season at home against Watford on Sunday.
West Ham and Manchester United played out a tiresome goalless draw at the London Stadium - although the result was enough to see Jose Mourinho's side secure second place in the Premier League.
- Since Alex Ferguson retired at the end of the 2012-13 season, no Premier League team has drawn more matches 0-0 than United (19, level with Southampton). But I've got other things if it's not renewed.