Schalke are flying high this season and are second in the Bundesliga behind freshly-crowned champions Bayern Munich.
However, his domestic season has been cut short with a suspected broken ankle that he suffered in the Ruhr derby against Schalke, where his loan side lost 2-0.
Reus did manage to test Fahrmann on 67 minutes after Schalke survived a penalty appeal when Christian Pulisic went to ground, and the US worldwide fizzed a first-time shot over the bar four minutes later from the German's cross.
Batshuayi sustained the injury after a challenge by former Spurs player Benjamin Stambouli
Dortmund dropped to fourth, the last qualification place for the Champions League, five points ahead of Hoffenheim, Eintracht Frankfurt and Leipzig.
Amine Harit and Guido Burgstaller fired efforts wide as the hosts continued to dominate the opening exchanges, with the derby played at a typically ferocious pace.
Konoplyanka's effort proved a sighter as he hammered Schalke in front in the 50th minute.
Second-half goals from Yevhen Konoplyanka and Naldo gave Schalke an eight-point cushion over fifth-place Leipzig with four rounds remaining.
Batshuayi could be set to return to Chelsea for treatment.
However, Dortmund conceded again seven minutes from time when Naldo drilled a low free-kick into the bottom-left corner of the net to seal an important win for Domenico Tedesco's men.
The day got even worse for Dortmund in stoppage-time as Batshuayi left the field on a stretcher after seemingly damaging his ankle in a challenge from Benjamin Stambouli.