President Bashar al-Assad is warning the West against attacking Syria as President Donald Trump's global allies make preparations to join the United States in any military action against the regime in response to last week's suspected chemical attack.
Macron said France had proof the Syrian regime has used chlorine as a weapon, and told French TV channel TF1 that he was in close discussions with Trump.
But she said the United States holds Russian Federation and Syria responsible for the incident.
Mattis said he personally believes Syria is guilty of an "inexcusable" use of chemical weapons, while noting that the worldwide fact-finding team would likely fall short of determining who was responsible. Syria and Russian Federation denied the attack.
Earlier, the US President Donald Trump has tweeted that Russian Federation should "get ready" for the firing of missiles at Syria as the US continues to affirm that the Syrian government was behind an alleged chemical attack on Saturday. "You shouldn't be partners with a Gas Killing Animal who kills his people and enjoys it!"
Erdogan says Turkey's warming ties with Russian Federation and Iran are "not an alternative" to its traditional ties to the West, adding that Ankara would "fight until the end" against Russia's support for Syrian President Bashar Assad and against US support to a Syrian Kurdish militia that Ankara has labelled a terrorist group.
"This has Cold War ramifications - if we get a USA pilot shot out of the sky by a Russian missile - that has tinderbox written all over it".
A joint statement by the civil defense group and the medical society said that more than 500 people, mostly women and children, were brought to medical centers complaining of difficulty breathing, foaming at the mouth and burning sensations in the eyes. A Syrian government air base near Homs, which is said to be home Iranian fighters allied with Assad, was struck by missiles.
But across Western capitals opposition to military action also grew.
USA officials have refused to rule out direct military engagement with Russian Federation, with the White House saying "all options are on the table".
British Prime Minister Theresa May has summoned her Cabinet back from vacation to discuss military action against Syria over an alleged chemical weapons attack.
The U.S., France and Britain have been consulting about launching a military strike, and President Donald Trump tweeted Wednesday that missiles "will be coming".
Activists, rescue workers and medics say dozens of people died in the formerly rebel-held town of Douma on Saturday. The message notably did not rule out plans to attack Syria in retaliation for the weekend's suspected chemical attack on civilians at the hands of the Assad regime.
He also noted that France would decide whether to strike Syria when all the necessary information has been gathered. "Yes, every day since the beginning of the week, our teams are working closely together and we will have decisions to make when the times comes, when we will judge it to be useful and effective", Macron said.
Mattis said that although the United States has no hard proof, he believes the Syrian government is responsible for Saturday's attack. She called Syrian President Bashar al-Assad a "monster" who "no civilized government would have anything to do with".
In case the regime captures East Ghouta, Israel may consider the situation a blow to its security while the US and some European Union countries, including France, will be disturbed with the idea that Russian Federation would be free to clear the capital, therefore the route to the Mediterranean Sea, from the opposition groups.
The Russian ministry says 1,500 left the town in the past 24 hours.