Anthony Martial is back and Zlatan Ibrahimovic trained with his United team-mates ahead of the match, but Ander Herrera, Marcos Rojo, Phil Jones and Daley Blind remain sidelined.
Shaw made his return to the United starting lineup in the Champions League against CSKA Moscow in December.
However, Jose will reportedly change a winning team. Sanchez remains one of the most experienced players in a relatively young United team with most number of Champions League appearances to his kitty.
The first leg tie between the two teams finished in a goalless stalemate in Spain, and United will be confident that home advantage on Tuesday night will work in their favour. "I think tomorrow is a very hard match".
Doubters may have been quietened by successive wins over Chelsea, Crystal Palace and Liverpool, with a mix of performances ultimately doing enough to give the Red Devils a cushion in second place.
Delivering two major trophies last season and a return to the Champions League represented a foundation base upon which to build, and while they are not at Europe's elite level yet there are signs that something big is building.
"Tomorrow is more important than Saturday [against Liverpool] because Saturday was a match for points that we still have 24 more points to discuss, 24 more points to try to finish in the top four", Mourinho said, as per Manchester United's official website.
A Sevilla victory would mean qualifying for the quarterfinals for the first time in six decades, and the historic chance has drawn the largest crowd of Sevilla fans so far to attend an away match in the Champions League knockout stage, reports Efe. "I'm really happy with Marcus".