"She would absolutely do it", he said.
But if Winfrey is smart - and she is - she will wonder whether the message she tried to convey will get lost in all the political chatter.
"No, I like Oprah, I don't think she's going to run", he told reporters today. I do think she is intrigued by the idea, I do think that. "Absolutely. But in terms of where she stands on a number of positions, I would find a lot of problems with that", Sanders said.
Do you think Oprah will run for office in a few years? Would Oprah's other longtime BFF, Stedman Graham, be called "First Man" or "First Boyfriend"?
In a television interview early a year ago, Winfrey indicated that Trump's election had changed her mind about whether she lacked experience for America's highest office.
While the president has nothing but nice things to say about the media mogul, she hasn't been quite as kind in return. It was very important for her because it would be the first time people heard from her in any detail about the Me Too movement.
Most actors and actresses at the Golden Globes, including Winfrey, wore black as an expression of protest against sexual harassment in the workplace and gender disparities in compensation and career advancement. "I don't", King said on the show.
Meryl Streep also reiterated her support of the idea, stating: "Whether she is leading us to the candidate we need of whether she herself is a candidate, she sets the bar pretty high on campaign talk".
The honorary award is given to performers for their "outstanding contributions to the world of entertainment" at the annual movie and television awards show.
The TV and movie star also praised the work of the Hollywood Foreign Press Association. "I thought they'd be talking about it because I knew it was going to be good".