"I want tonight to express gratitude to all the women who have endured years of abuse and assault because they, like my mother, had children to feed bills, to pay and dreams to pursue", she said.
Winfrey, in September and October, publicly dismissed the notion of seeking the nation's highest office, though she noted that Trump's victory made her rethink the requirements of the office.
Oprah: So, Barry, do you think I could do it? She's not thinking that, 'Oh, since I did this speech, I qualify to be president or I even want to be president'. She knew that she met the moment, but the reaction to the speech has been sort of overwhelming to her. Once upon a time, military service, political experience, a policy portfolio and national-security chops were mandatory to plausibly run for president. You know I did one of her last shows.
"Thanks to the fearless voices we've heard this week, many more will now be emboldened to come forward EVERY time this happens", Oprah concluded. If she ran and lost, she'd become a failed presidential candidate and could presumably never quite return to being Oprah Winfrey again. The poll reported that 48 percent of likely USA voters would choose Oprah over Trump.
There have been whispers about the possibility of Winfrey running for the presidency for a while now.
"Thanks for your VOTE of confidence!" responded Winfrey on Twitter.
After college, she went into journalism before reigning for 25 years as queen of the United States talk show, ushering in an era of confessional television before becoming the first black woman to own a television network.
At the start of the Golden Globes on Sunday, host Seth Meyers playfully encouraged Winfrey to run against Trump. In a show of solidarity Winfrey, who was honoured with the Cecil B. DeMille Award at the ceremony, joined the majority of actors who choose to wear black. It's no secret that he was a powerful man with powerful friends, but Seal, buddy, come on.
Trump's daughter Ivanka endorsed Oprah's message, if not a political future, in a tweet Monday: "Just saw @Oprah's empowering and inspiring speech at last night's #GoldenGlobes".