If the wind chills range from 15 to 25 degrees below zero as expected in much of western and northern Pennsylvania on Saturday, the onset of frostbite can take as little as 10 minutes.
Winds chills will be well below zero this weekend, with some areas feeling like it is minus 40.
Dedham, Massachusetts, had 19 inches of snow, according to the National Weather Service. Meteorologists also predicted that thawing should begin on Monday and bring some relief. The weather has been blamed for at least 18 deaths in the past few days and temperatures are set to plunge further, with the cold snap for Americans far from over.
Three of the recorded deaths occurred in North Carolina, while one happened in SC.
At least 22 people in the United States have died in brutal cold weather following a massive winter storm causing the weather to become even more unbearable across the Northeast and Midwest of the country.
Six deaths were reported in Wisconsin, four in Texas, three in North Carolina, two in Virginia and one each in Ohio, Massachusetts, Michigan, Missouri, North Dakota, New York and SC.
A pedestrian walks through blinding snow across the Brooklyn Bridge during Storm Grayson in New York City.
Outside Boston in the northeastern state of MA, a state Water Resources Authority worker collapsed into a snow bank while shoveling snow and died on Friday.
Among the dead was a 64-year-old man who died of hypothermia in Akron, Ohio.
In South Carolina, a man was killed after his pickup slid on icy roads, hitting a median and several trees, according to the Kershaw County Coroner. Temperatures in Boston and other parts of New England are not expected to climb out of the single digits, Fahrenheit, this weekend.
Video from a resident of Hull, just to the southeast of Boston, showed the icy mess inundating one street with water above the wheel wells of cars and coming up to the doors of homes.
On Thursday afternoon, the tide gauge at Boston Harbor matched its record at 15.1 feet - previously set during the blizzard of 1978.
The storm flooded streets in some communities in coastal MA, turning roads into slushy rivers. Firefighters and even the National Guard scrambled to rescue dozens of residents stranded by freezing water pushing from the Atlantic into coastal MA.