At this moment, Ibuprofen is considered to be the broadest male endocrine-disturbing drug from all chemical classes. It also brings fertility problem in women. Earlier this year, a study was published that found ibuprofen was associated with a 31-percent increase in cardiac arrest risk among users.
They fear long-term use may be to blame for rising levels of infertility. Inhibition of testosterone levels was found to be significant and dose-dependent after 24 and 48 hours of ibuprofen exposure (in doses which corresponded to the oral doses used in the trial). David M. Kristensen, study co-author and a senior scientist in the Department of Neurology at Copenhagen University Hospital explained that these drugs were damaging the sperm production in the testes and also acting against the male hormone testosterone and thus could be called "antiandrogenic".
OTC medicines have been found to have drawbacks
The study tested the effects of 600mg of Ibuprofen on volunteers - three tablets - as well as studying the effect on cells taken from testicles in the laboratory. The researchers are now examining about more such drugs to find out their effect on men's fertility. Fourteen of them took a daily dosage of ibuprofen that many professional and amateur athletes take: 600 milligrams twice a day.
But given how athletes routinely use the medication to help with recurring sports injuries, experts say this is something we definitely need to stay aware of - because despite how some might abuse it, ibuprofen isn't something that was ever meant to be taken casually. The others acted as a control.
"The safety and efficacy of active ingredients in these products has been well documented and supported by decades of scientific study and real-world use", said Mike Tringale, a spokesman for the association, according to Fox News.
He said investigating ibuprofen-induced compensatory hypogonadism is crucial as the disorder is "generally associated with smoking and ageing".
After 14 days, the men in the ibuprofen group had developed a hormonal imbalance that resulted in compensated hypogonadism.
Ibuprofen is termed as an anti-inflammatory drug which is non-steroidal in nature.
As a fun added bonus, previous research has found a link between low testosterone levels and premature death. The condition develops when the body has to boost testosterone levels because normal production has fallen. As mentioned above, we're not sure if the compensated hypogonadism is reversible after long-term use, but it's always better to be safe than sorry.