The star-studded guest list is rumored to include celebrities, like Beyoncé and Jay-Z, Kris Jenner, and Meghan Markle, who will watch the lovebirds say their "I do's" at the city's Contemporary Arts Center.
The tennis champion, 36, is saying "I do" to the Reddit co-founder, 34, in an intimate ceremony in New Orleans, Louisiana.
According to reports, the event will take place at the Contemporary Arts Centre at New Orleans.
The outlet reports that the nuptials are so shrouded in secrecy that the guests haven't even been told of the wedding location.
All guests wore white, with LaLa Anthony, Ciara, and the Williams sisters posing for a photo shared exclusively with PEOPLE. It's a special city for Serena and somewhere she has always loved. The hall will be totally transformed'.
The bride-to-be and her guests, including Venus and Ciara, all stayed at the Baccarat Hotel and were transported around the Big Apple in a party bus, dropping them off at top seafood restaurant Legasea for a private dinner, followed by a night of clubbing.
Both parents wouldn't dream of not having her there. They are totally and utterly besotted with her'.
Williams and Ohanian announced their engagement in December 2016.
"She quickly became a confidante I would text when I was traveling", Meghan's said of their friendship. I'm definitely coming back.
Serena had been linked to Bulgarian tennis player Grigor Dimitrov, but the couple split up after a brief relationship.