It is unclear which substance, but the charge is specific to possession of a schedule I or II narcotic, authorities told THR.
Rose McGowan was arrested and booked on Tuesday for drug possession, before being released on a $5,000 unsecured bond.
The Metropolitan Washington Airports Authority said McGowan left personal belongings on United flight 653 after arriving at Dulles on January 20.
McGowan turned herself in in Loudoun County, Virginia, and was served with the arrest warrant.
Metropolitan Washington Airports Authority spokesman Andrew Trull says in an email Tuesday night that McGowan has surrendered to Airports Authority Police.
After apparently learning about the charge last month, McGowan, whose name has hit the headlines with the onslaught on Weinstein coverage, tweeted: "Are they trying to silence me?"
McGowan is among several actresses who have said movie mogul Harvey Weinstein forced them into unwanted sex. "What a load of HORSES-", she tweeted. McGowan has been a key figure in recent allegations against Hollywood elite for sexual harassment and assault. It's said cocaine was found inside a wallet she dropped.
The Charmed star was allegedly raped by Weinstein at the Sundance Film Festival in 1997, and the Times reported that she received a $100,000 settlement in the wake of the incident.