Adepoju has warned the Eagles not to be complacent heading into the tie following news that Argentina captain and talisman Lionel Messi will not be playing.
The Barcelona star will miss La Albiceleste's friendly against the Super Eagles after withdrawing from the team to return to Spain.
"His [Messi] absence doesn't mean we're facing a lesser Argentina".
On the possibility of Argentina humiliating Nigeria, he said: "It will be very hard to say, but I know that Argentina is a good side".
"South American teams always pose a threat for us especially at the senior level in competitive games and I think despite Argentina's collection of individual quality players, Super Eagles coaches should use Tuesday's match to further pick up technical details of them which is same as other South American teams as guide going into next year's World Cup in Russia".
"He is the one who moves the ball in the team but other players are equally good, so when we're talking about their striking area, the midfield and the defence, our boys [Super Eagles] must be at their best".
Messi played the full duration of the first match in Moscow on Saturday as a late Sergio Aguero goal secured a 1-0 win over Russian Federation at the newly refurbished Luzhniki Stadium.
Against the Super Eagles, Clarin Deportes reports on Monday that Sampaoli had chose to play Dybala behind Aguero this time round.
Also, Adepoju insists that not minding the outcome, Gernot Rohr's men must take plenty of positives which will help their preparations for the 2018 Fifa World Cup.
The former African Footballer of the Year posited that though Argentina struggled before securing the World Cup ticket, they boast one of the most intimidating collection of quality players in the world.
"It is a lot (of games), but we will try to take care of ourselves to go into the World Cup in the best fashion".