Ghana duo Christian Atsu and Thomas Teye Partey have been shortlisted for the 2017 African Player of the Year gong.
Liverpool are also represented by Egyptian winger Mohamed Salah and RB Leipzig's Anfield bound Guinea midfielder Naby Keita.
The winners of the CAF awards will be announced in a ceremony to take place in Accra, Ghana, on January 4.
There are four nominees from Spain's La Liga and France's Ligue 1, two from the German Bundesliga, but none from Italy's Serie A.
Portuguese outfit Porto supply the most players with Algerian Yacine Brahimi, Malian Moussa Marega and Cameroonian Vincent Aboubakar listed.
Ekong has been impressive for both club and country this campaign, starting in all the Super Eagles' World Cup qualifiers as the team clinched a sixth ticket.
Uganda goalkeeper Denis Onyango, who plays for South African club Mamelodi Sundowns, is among 30 nominees for the Africa-based Player of the Year, an award he won last year.
The other Nigerian player nominated is Al Ahly striker Junior Ajayi who will vie for honours in the African Player of the Year - based in Africa award.
The winners will be decided by votes from head coaches and technical directors of the national associations affiliated to CAF, members of the CAF media committee, members of the technical and development committee and a panel of experts.