Watford meanwhile, will be looking to bounce back from their heavy 6-0 defeat at the hands of Man City in their last Premier League fixture.
There is better injury news, however, regarding Sead Kolasinac, who was forced off whilst playing for Bosnia on Tuesday night with the left-sided defender expected to be available for the game against the Hornets.
"I don't think he will be available before the next worldwide break". "But he trained on his own and the first signs are positive, so we made a decision to give him a test tomorrow", he added.
"Koscielny has a definite final test tomorrow".
The Italian-owned side are seriously impressing this season, and will pose a tough task for our boys, despite our top form coming into the match.
"We've lost Mustafi for about four to six weeks", said Gunners manager Wenger.
'If he has no pain on his Achilles tendon he will play'.
"It's always hard. The player I expected to lose the least during the break was Mustafi, because first of all I was not sure if he would play and secondly Germany were already qualified so you didn't expect him to be out injured because the games would be less intense".
Koscielny has to be nursed through the season due to the long-standing problem; meaning a reduced training load.
Alexis Sanchez will be assessed when he returns from worldwide duty after he received "special treatment" following Chile's 3-0 defeat to Brazil.
"The minor problem we have with Sead Kolasnic, we'll check him today, it's a hip problem", the Frenchman said on Thursday.